PP2A and tumor radiotherapy

PP2A and tumor radiotherapy

Blog Article

Abstract Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that iphone 12 price florida serves as a key regulator of cellular physiology in the context of apoptosis, mitosis, and DNA damage responses.Canonically, PP2A functions as a tumor suppressor gene.However, recent evidence suggests that inhibiting PP2A activity in tumor cells may represent a viable approach to enhancing tumor sensitivity to chemoradiotherapy as such inhibition can cause cells to enter a disordered mitotic state that renders them more susceptible to cell death.Indeed, there is evidence that inhibiting PP2A can slow tumor growth following radiotherapy in a range of cancer types including ovarian cancer, liver cancer, malignant glioma, pancreatic cancer, and nasopharyngeal carcinoma.

In the present review, we discuss current understanding of 92-95 civic k-swap mounts the role of PP2A in tumor radiotherapy and the potential mechanisms whereby it may influence this process.